At the end of this process the T-cell is either activated or remains inactive. Robert, Philippos Demetriou, Michael L. Vimeo, Twitter, Googlemaps Permit embedded content and cookies from third party providers. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. Jerne for discovering the principle for producing monoclonal antibodies and former Director at the Max Planck Institute of Immunobiology, Freiburg. We only use this information for improving our services. This, however, could not be proved for the other molecules. You can personalize your cookie settings here: The Fr1da study is the first population-based approach for the early diagnosis type 1 diabetes associated autoimmunity in childhood.
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The large adhesion molecules accumulate around them in an outer ring. Researchers of the Helmholtz Centre for Infection Research HZI and the Braunschweig Integrated Centre of Systems Biology BRICSin collaboration with researchers at the University of Oxford UKhave now simulated the dynamic arrangement of these components using computer models and have subsequently been able to make inferences on the mechanisms involved in the formation of synapses.
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Print Send per email Share. Computer simulation of an immunological synapse with its characteristic ring-shaped structure.
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If all the components of the synapse are correctly positioned, activation of the immune cell will result.
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In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.
The Institute of Diabetes Research IDF focuses on the understanding of the natural history of type 1 diabetes, on the identification of mechanisms and predictive markers of the disease, and the translation of findings into trials to prevent type 1 diabetes in man. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy.
The antigen receptors are small and are repelled by the large adhesion molecules.